How is chromatin structure linked to gene regulation in eukaryotic cells?

How is chromatin structure linked to gene regulation in eukaryotic cells?

• A. DNA remains accessible regardless of histone modifications.
• B. DNA is wrapped around histones forming nucleosomes; acetylation and methylation modify histones to open or close chromatin; chromatin remodeling alters accessibility to transcription machinery.
• C. Transcription is determined solely by DNA sequence; chromatin plays no role.
• D. Only DNA methylation controls chromatin state; histone modification has no effect.

Answer: (B)